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Explore TYKnologyTM

Our pathbreaking research sheds
light on the role of TYK2 in psoriasis.

TYK2 pathway in psoriasis

Psoriasis is an immune-mediated disease characterized by the elevation of inflammatory cytokines regulated by several components. The tyrosine kinase 2 (TYK2) pathway plays a critical role in managing important inflammatory signals.1,2

For a deeper look at the TYK2 pathway, check out our video to see it in action.

Pro-Inflammatory Cytokines
Pro-Inflammatory Cytokines

The TYK2 pathway difference

The TYK2 pathway works within the immune system by regulating triggers of inflammation.1 The TYK2 pathway has not been shown to mediate signals involved in blood cell development and lipid metabolism.2-6

The TKY2 Pathway Difference
The TKY2 Pathway Difference

See the TYK2 pathway in action

TYK2 mediates the signaling pathways of inflammatory cytokines. These pathways are crucial in the cycle of chronic inflammation in immune diseases such as psoriasis.1,2 Watch the video to learn more.

See the TYK2 Pathway in Action

The BMS Commitment to Patients

BMS is committed to transforming patients' lives through science and to addressing unmet needs in dermatology.

Our research on the TYK2 pathway is a preeminent example of BMS leading the way with pathbreaking science to help patients prevail over serious immune-related diseases such as psoriasis.

References

  1. Mahil SK, Capon F, Barker JN. Update on psoriasis immunopathogenesis and targeted immunotherapy. Semin Immunopathol. 2016;38(1):11-27. doi: 10.1007/s00281-015-0539-8
  2. Baker KF, Isaacs JD. Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis? Ann Rheum Dis. 2018;77(2):175-187. doi: 10.1136/annrheumdis-2017-211555
  3. Diogo D, Bastarache L, Liao KP, et al. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS ONE. 2015;10(4):e012271. doi: 10.1371/journal.pone/0122271
  4. Dendrou CA, Cortes A, Shipman L, et al. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med. 2016;8(363):363ra149. doi: 10.1126/scitranslmed.aag1974
  5. Shimoda K, Kato K, Aoki K, et al. Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. Immunity. 2000;13(4):561-571. doi: 10.1016/s1074-7613(00)00055-8
  6. Richard AJ, Stephens JM. Emerging roles of JAK-STAT signaling pathways in adipocytes. Trends Endocrinol Metab. 2011;22(8):325-332. doi:10.1016/j.tem.2011.03.007